49ers players the Colts must game plan for in Week 7

The Indianapolis Colts (2-4) come off their most dominant performance of the season against the Texans in a 31-3 blowout. The Colts performed well in all three phases of the game, bouncing back after a heartbreaking loss against Baltimore.

This week’s test is much greater as Frank Reich’s team travels to San Francisco to take on the 49ers in a Sunday Night showdown. San Francisco has playmakers on both sides of the ball that can disrupt the Colts on any given play.

Indy will not have to deal with All-Pro tight end George Kittle who was placed on the injured reserve list two weeks ago while left tackle Trent Williams is doubtful on the final injury report.

Here are four 49ers that the Colts must game plan for in Week 7: