Jaguars vs. Colts: Prediction, point spread, odds, best bet

The Jacksonville Jaguars play the Indianapolis Colts on Sunday, and if you’re looking to do some last-minute betting research, you’re in luck! We’ll give you the latest point spread, money line odds and over/under number, as well as the information you’ll need to make the smartest bet.

The game starts at 1 p.m. ET and can be seen on FOX.

The Jaguars enter the season with high hopes after earning the AFC South title a year ago. The Colts, on the other hand, won just four games in 2022 and are beginning a new era with first-year head coach Shane Steichen and rookie quarterback Anthony Richardson.

Unsurprisingly, the Jaguars are a road favorite in Week 1:

• Point spread: Jaguars -4.5
• Money line: Jaguars -225
• Over-under: 46 points

Jaguars at Colts injury report:

Jacksonville will be without rookies Antonio Johnson and Tyler Lacy on Sunday and it has veteran defensive tackle DaVon Hamilton on the injured reserve.

The most impactful injury news is on the Colts’ side, though. The team downgraded running back Zack Moss from questionable to doubtful, meaning Deon Jackson is likely to start in the Indianapolis backfield.

Advice and prediction

The Jaguars have lost six straight at Lucas Oil Stadium, including a 34-27 loss last season. However, it’d be pretty shocking if they couldn’t handle a Colts squad in the early stages of a rebuild.

Prediction: Jaguars 30, Colts 13

Get more betting analysis and predictions at Sportsbook Wire.